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Meg Altman (Jodie Foster) and her daughter Sarah (Kristen Stewart) play a deadly game of cat and mouse with three intruders – Burnham (Forest Whitaker), Raoul (Dwight Yoakam) and Junior (Jared Leto) – during a brutal home invasion. But the “Panic Room” into which they escape is the very place that holds what the intruders and desperately seeking.