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Paul works as a waiter for Julia who runs a catering company. They go to set up for a function at the Perch estate. The rural world of Mrs. Perch, a well-to-do elderly lady in New York, is all abuzz in anticipation of her annual garden party, an small but elaborate affair held in a villa at the remote estate where she resides with her son Sydney. Among the guests is the town mayor, Caruthers. Unfortunately, thanks to an illegally imported plant fertilizer mixed with growth hormones which seeps into the ground, a local species of parasitic wasp mutates into significantly larger creatures. Mrs. Perch's upper class celebrants, slowed by the evening's festivities, are the ideal prey. The wasps burrow inside the bodies of the guests to emerge as creatures seven feet long. It is up to Paul and Julia, two catering staffers, to figure out how to stop the giant wasps, and, while they are at it, and whether whatever spark or buzz between them is another risk worth taking. They realize that the wasps reproduce through their stingers, also ovipositors, as juvenile wasps emerge from human hosts who are killed in the process. Paul, Julia, Caruthers, Sydney, Mrs. Perch, and Flora (the cook) take refuge inside the house, barricading themselves in from the fierce attack. Following a car crash outside, the phone lines are dead, leaving the survivors cut off from the outside world. They decide to hide in the basement, but before they can, it becomes clear that it is too late for Mrs. Perch, who has already been stung; a wasp emerges from her body, killing her and Flora. Paul, Julia, Caruthers, and Sydney escape to the basement. They make a plan to escape using the catering van, but Paul has left his keys outside. He manages to retrieve the keys and kill a wasp. Sydney, however, has also been stung, and this time the emergent wasp controls its host until Paul and Julia subdue him. Paul, Julia, and Caruthers begin creep around the house to find an exit. The three suddenly under attack, Caruthers sacrifices himself, allowing Paul and Julia to escape into another room. They kill an invading wasp and get outside, but Paul is taken by a wasp and flown to a nest, where he recognizes the queen that emerged from Mrs. Perch and which still controls Sydney, who attempts to force something into Paul's mouth. Julia appears and kills Sydney, rescues Paul, and blows up the nest. As they drive away, a surviving wasp, its body on fire, attacks the car. Paul rams the car into a tree and kills the wasp, but the crash knocks him and Julia out. Paul and Julia awaken to the arrival of the authorities. They are placed in the back of an ambulance where they finally express their feelings for each other. Screams make it clear that several giant wasps remain active, accompanied by flying wasp-cow hybrids, and are killing the police officers — and, perhaps, the new couple.